Abstract Encorafenib plus binimetinib in unresectable advanced or metastatic BRAFV600-mut melanoma, real-world evidence in Spain (GEM 2002 – BECARE) Soria A, et al. Background: Combined BRAF/MEK inhibitors have demonstrated efficacy and tolerability in phase…s.mengoni1 Dicembre 2023
Abstract COLUMBUS 7-year update: a randomized, open-label, phase III trial of encorafenib+binimetinib vs vemurafenib or enco in patients with BRAF V600-mutant melanoma Schadendorf D, et al. Background: In the randomized, 2-part, multicenter, open-label, phase III COLUMBUS study,…s.mengoni1 Dicembre 2023
Abstract Real-world treatment patterns and outcomes among patients with BRAF+ metastatic melanoma refractory to first-line immunotherapy Truong TG, et al. Background: Many patients with BRAF+ metastatic melanoma (MM) experience tumor progression…s.mengoni1 Dicembre 2023
Abstract Overall survival in patients with metastatic BRAF V600-mutant melanoma treated with encorafenib plus binimetinib: comparing real-world vs clinical trial data In GK, et al. Background: ENCO+BINI, a combination BRAF and MEK inhibitor therapy, prolonged OS…s.mengoni1 Dicembre 2023
Abstract Five-year survival after intermittent targeted therapy and anti-PD1 in stage IV melanoma: an update of the IMPemBra trial Hoeijmakers L, et al. Background: IMPemBra was the first trial testing intermittent, short-term, dabrafenib and…s.mengoni1 Dicembre 2023
Abstract A randomised phase II study of intermittent versus continuous dosing of targeted therapy in patients with BRAFV600 mutant advanced melanoma (INTERIM) Gupta A, et al. Background: BRAF+MEK inhibitors extend life expectancy of BRAF V600 mutant advanced…s.mengoni1 Dicembre 2023
Abstract Melanoma brain metastases: immunotherapy or target therapy? A systematic review and meta-analyses Onofrio L, et al. Background: Among the most common causes of death in patients with…s.mengoni30 Novembre 2023
Abstract Occurence of irAEs and flares in patients with preexisting autoimmune diseases: a real world scenario Vitale M, et al. Background: Cancer patients (pts) with autoimmune diseases have been excluded from…s.mengoni30 Novembre 2023
Abstract Braf variant allele frequency’s role in predicting response to targeted therapy in metastatic melanoma: a retrospective analysis Cerro M, et al. Background: BRAF V600 mutations occur in 50% of cutaneous melanoma patients…s.mengoni30 Novembre 2023
Abstract End-of-life intensive care in advanced melanoma patients (pts): incidence and type of systemic anticancer therapy (SACT) within the last month of life Buriolla S, et al. Background: The administration of SACT in the last month of life…s.mengoni29 Novembre 2023